反応 #595396

反応方程式

p-tolylhydrazine hydrochloride

1-carbethoxy-4-piperidone

→

desired product

収率 86.0%

Ethyl 8-Methyl-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate

収率 86.0%

溶媒

EtOH

反応条件

後処理

1. 1
   温度heated
2. 2
   温度to reflux for 2 hours
3. 3
   その他The reaction mixture was removed
4. 4
   温度from heat
5. 5
   ろ過The resulting mixture was filtered
6. 6
   洗浄washed with 50% aqueous EtOH

実験手順

Following a literature procedure (Harbert et al., J. Med. Chem. 1980, 23, 635-643) p-tolylhydrazine hydrochloride (0.500 g, 3.15 mmol) and 1-carbethoxy-4-piperidone (0.18 mL, 1.17 mmol) were suspended in EtOH (0.880 mL) and heated to reflux for 2 hours. The reaction mixture was removed from heat and allowed to stand overnight at ambient temperature. The resulting mixture was filtered and washed with 50% aqueous EtOH to afford the desired product as a beige powder (259 mg, 86%).

出典