反応 #595378

反応方程式

3-bromo-1H-indazole

sodiumhydride

3,5-dimethylbenzene-1-sulfonyl chloride

→

3-bromo-1-(3,5-dimethylphenylsulfonyl)-1H-indazole

収率 38.3%

溶媒

DMF

反応条件

後処理

1. 1
   workup.STIRRINGthe reaction mixture was stirred for another 2 h at room temperature
2. 2
   その他The reaction was quenched by the addition of water
3. 3
   ろ過the formed solids were filtered off
4. 4
   洗浄washed with little methanol
5. 5
   その他The solids were dried

実験手順

3-bromo-1H-indazole (3 gram; 15 mmol) was dissolved in 30 ml DMF, followed by the addition of sodiumhydride (850 mg, 21 mmol). After stirring for 20 min at room temperature, 3,5-dimethylbenzene-1-sulfonyl chloride (4.4 gram, 21 mmol) was added and the reaction mixture was stirred for another 2 h at room temperature. The reaction was quenched by the addition of water and the formed solids were filtered off and washed with little methanol. The solids were dried to obtain 3-bromo-1-(3,5-dimethylphenylsulfonyl)-1H-indazole (2.1 gram) as a white solid.

出典