反応 #595376

反応方程式

3-bromo-1H-indazole

triethylamine

2-cyanobenzene-1-sulfonyl chloride

→

3-bromo-1-(2-cyanophenylsulfonyl)-1H-indazole

収率 97.4%

溶媒

CH2Cl2

反応条件

後処理

1. 1
   濃縮After completion the reaction mixture was concentrated under reduced pressure
2. 2
   その他the product was purified on SiO2 using 0% to 50% ethyl acetate in heptane as the eluent

実験手順

To a solution of 3-bromo-1H-indazole (200 mg, 1.02 mmol) in 2 ml CH2Cl2 was added triethylamine (308 mg, 3.05 mmol) and 2-cyanobenzene-1-sulfonyl chloride (205 mg, 1.02 mmol). The reaction mixture was stirred overnight at room temperature. After completion the reaction mixture was concentrated under reduced pressure and the product was purified on SiO2 using 0% to 50% ethyl acetate in heptane as the eluent to give 3-bromo-1-(2-cyanophenylsulfonyl)-1H-indazole (360 mg) as a yellow solid.

出典