反応 #595375

反応方程式

3-bromoindazole

triethyl amine

2-(trifluoromethyl)benzenesulfonyl chloride

→

3-bromo-1-(2-(trifluoromethyl)phenylsulfonyl)-1H-indazole

収率 86.9%

溶媒

CH2Cl2

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated under reduced pressure
2. 2
   その他the residue was purified on SiO2 using 5% to 20% ethyl acetate in heptane

実験手順

To a suspension of 3-bromoindazole (500 mg, 2.54 mmol) in 8 ml CH2Cl2 was added triethyl amine (1.06 ml, 7.61 mmol) at room temperature. To this yellow solution was added 2-(trifluoromethyl)benzenesulfonyl chloride (0.392 ml, 2.54 mmol) and the reaction mixture was stirred for 3 h at room temperature. The reaction mixture was concentrated under reduced pressure and the residue was purified on SiO2 using 5% to 20% ethyl acetate in heptane to give 3-bromo-1-(2-(trifluoromethyl)phenylsulfonyl)-1H-indazole (894 mg)

出典