反応 #595373

反応方程式

4-bromo-2,5-difluorobenzoic acid

methanol

→

title compound

methyl 4-bromo-2,5-difluorobenzoate

反応条件

後処理

1. 1
   濃縮The mixture was concentrated
2. 2
   workup.ADDITIONThen MeOH was added
3. 3
   濃縮the mixture was concentrated again
4. 4
   その他The residue was purified by flash chromatography (Pentane/EtOAc=4:1)

実験手順

A mixture of 4-bromo-2,5-difluorobenzoic acid (i-7b) (0.48 g, 2 mmol) and methanol (10 mL, saturated with gaseous HCl) was heated at 65° C. for 2 h. The mixture was concentrated. Then MeOH was added and the mixture was concentrated again. The residue was purified by flash chromatography (Pentane/EtOAc=4:1) to give the title compound. LCMS (ESI) calc'd for C8H5BrF2O2 [M+H]+: 251. found: 251.

出典