反応 #595367

反応方程式

BnBr

methyl 2,4-dihydroxybenzoate

K2CO3

→

title compound

methyl 4-(benzyloxy)-2-hydroxybenzoate

溶媒

acetone

反応条件

後処理

1. 1
   温度The mixture was heated at 60° C. for 24 h
2. 2
   温度The reaction mixture was cooled down
3. 3
   ろ過filtered
4. 4
   濃縮The filtrate was concentrated

実験手順

To a solution of methyl 2,4-dihydroxybenzoate (i-1a) (1.68 g, 10 mmol) in acetone (30 mL) was added K2CO3 (2.76 g, 20 mmol). The mixture was stirred at rt for 5 h, followed by the addition of BnBr (1.88 g, 11 mmol). The mixture was heated at 60° C. for 24 h. The reaction mixture was cooled down, filtered. The filtrate was concentrated to afford the title compound. LCMS (ESI) calc'd for C15H14O4 [M+H]+: 259.1. found: 259.1.

出典