反応 #595353

反応方程式

compound

Methyl 2-(4-chlorophenyl)-4-(hydroxymethyl)-1,3-oxazole-5-carboxylate

thionyl chloride

→

Methyl 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-oxazole-5-carboxylate

反応条件

後処理

1. 1
   その他The excess thionyl chloride is removed under reduced pressure
2. 2
   洗浄The mixture is washed once with 2 ml of sat. aqueous sodium bicarbonate solution
3. 3
   乾燥The organic phase is dried over magnesium sulfate
4. 4
   その他the solvent is removed under reduced pressure
5. 5
   その他The product obtained
6. 6
   その他is used without further purification in the subsequent reactions

実験手順

100 mg (0.43 mmol) of the compound from Example 44A, together with 0.24 ml (3.24 mmol) of thionyl chloride, are stirred at RT for 8 h. The excess thionyl chloride is removed under reduced pressure and the residue is taken up in about 5 ml of ethyl acetate. The mixture is washed once with 2 ml of sat. aqueous sodium bicarbonate solution. The organic phase is dried over magnesium sulfate and the solvent is removed under reduced pressure. The product obtained is used without further purification in the subsequent reactions.

出典