反応 #595352

反応方程式

compound

Methyl 2-(4-chlorophenyl)-4-[(methoxymethoxy)methyl]-1,3-oxazole-5-carboxylate

hydrochloric acid

→

Methyl 2-(4-chlorophenyl)-4-(hydroxymethyl)-1,3-oxazole-5-carboxylate

溶媒

methanol

water

反応条件

後処理

1. 1
   抽出extracted three times with in each case 10 ml of diethyl ether
2. 2
   乾燥The combined organic phases are dried over magnesium sulfate
3. 3
   その他the solvent is removed on a rotary evaporator
4. 4
   その他The product obtained
5. 5
   その他is used without further purification in the subsequent reaction

実験手順

144 mg (0.52 mmol) of the compound from Example 43A are initially charged in 0.5 ml of methanol, and 0.13 ml of 4 N hydrochloric acid are added. 3 drops of conc. hydrochloric acid are then added. The reaction mixture is stirred at RT for 8 h. The mixture is then diluted with about 5 ml of water and extracted three times with in each case 10 ml of diethyl ether. The combined organic phases are dried over magnesium sulfate and the solvent is removed on a rotary evaporator. The product obtained is used without further purification in the subsequent reaction.

出典