反応 #595350

反応方程式

hydrochloric acid

compound

2-(4-Chlorophenyl)-4-[(methoxymethoxy)methyl]-1,3-oxazole-5-carbaldehyde

dioxane

sodium hydroxide

→

2-(4-Chlorophenyl)-4-[(methoxymethoxy)methyl]-1,3-oxazole-5-carboxylic acid

溶媒

water

water

反応条件

後処理

1. 1
   ろ過The mixture is then filtered through Celite, which
2. 2
   洗浄is washed with warm water
3. 3
   その他The filtrate obtained
4. 4
   抽出extracted three times with in each case 20 ml of diethyl ether
5. 5
   乾燥The combined organic phases are dried over magnesium sulfate
6. 6
   その他the solvent is removed on a rotary evaporator
7. 7
   その他The residue is purified by preparative HPLC (column: YMC GEL ODS-AQ S-5/15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5)

実験手順

556 mg (2.25 mmol) of the compound from Example 41A and 14.7 ml of dioxane are added to a suspension of 802 mg (4.72 mmol) of silver(I) nitrate in 2 ml of water. A solution of 193 mg (4.84 mmol) of sodium hydroxide in 7.8 ml of water is then added slowly. The mixture is stirred at RT for 3 h. The mixture is then filtered through Celite, which is washed with warm water. The filtrate obtained is acidified by addition of 1 N hydrochloric acid and extracted three times with in each case 20 ml of diethyl ether. The combined organic phases are dried over magnesium sulfate and the solvent is removed on a rotary evaporator. The residue is purified by preparative HPLC (column: YMC GEL ODS-AQ S-5/15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5).

出典