反応 #595347

反応方程式

compound

[5-(4-Chlorophenyl)-1,3-oxazol-4-yl]methanol

thionyl chloride

→

4-(Chloromethyl)-5-(4-chlorophenyl)-1,3-oxazole

反応条件

後処理

1. 1
   その他excess thionyl chloride is then removed under reduced pressure
2. 2
   洗浄washed once with 2 ml of sat. aqueous sodium bicarbonate solution
3. 3
   乾燥The organic phase is dried over magnesium sulfate
4. 4
   その他the solvent is removed on a rotary evaporator
5. 5
   その他The product obtained
6. 6
   その他is used without further purification in the subsequent reactions

実験手順

269 mg (0.77 mmol) of the compound from Example 38A are initially charged in 0.43 ml (5.85 mmol) of thionyl chloride. The reaction mixture is stirred at RT for 12 h, and excess thionyl chloride is then removed under reduced pressure. The residue is taken up in 5 ml of ethyl acetate and washed once with 2 ml of sat. aqueous sodium bicarbonate solution. The organic phase is dried over magnesium sulfate and the solvent is removed on a rotary evaporator. The product obtained is used without further purification in the subsequent reactions.

出典