反応 #595341

反応方程式

compound

[2-(4-Chloro-3-methylphenyl)-1,3-oxazol-4-yl]methanol

thionyl chloride

→

4-(Chloromethyl)-2-(4-chloro-3-methylphenyl)-1,3-oxazole

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他The solvent is then removed on a rotary evaporator
2. 2
   その他The residue is used without further purification in the subsequent reactions

実験手順

136 mg (0.61 mmol) of the compound from Example 27A are suspended in 2 ml of dichloromethane. The suspension is cooled to 0° C., and 49 μl (0.67 mmol) of thionyl chloride are added slowly. The reaction solution is stirred at RT overnight. The solvent is then removed on a rotary evaporator. The residue is used without further purification in the subsequent reactions.

出典