反応 #595340

反応方程式

lithium aluminum hydride

compound

Ethyl 2-(4-chloro-3-methylphenyl)-1,3-oxazole-4-carboxylate

water

sodium hydroxide

→

[2-(4-Chloro-3-methylphenyl)-1,3-oxazol-4-yl]methanol

溶媒

THF

THF

反応条件

後処理

1. 1
   温度The reaction solution is then once more cooled to 0° C.
2. 2
   workup.STIRRINGThe mixture is stirred at RT overnight
3. 3
   その他The precipitate formed
4. 4
   ろ過is filtered off
5. 5
   その他a rotary evaporator
6. 6
   その他The residue is used without further purification in the subsequent reaction

実験手順

46 mg (1.22 mmol) of lithium aluminum hydride are initially charged in 8.0 ml of THF and cooled to 0° C. A solution of 161 mg (0.61 mmol) of the compound from Example 26A in 2.5 ml of THF is then added dropwise. The mixture is stirred at RT for 2 h. The reaction solution is then once more cooled to 0° C., and 0.2 ml of water and 0.4 ml of 1 N aqueous sodium hydroxide solution are added. The mixture is stirred at RT overnight. The precipitate formed is filtered off, and the filtrate is freed from the solvent using a rotary evaporator. The residue is used without further purification in the subsequent reaction.

出典