反応 #595321

反応方程式

Cyclopropanesulfonyl chloride

BuOH

pyridine

→

oil

収率 71.0%

Butyl cyclopropanesulfonate

収率 71.0%

反応条件

後処理

1. 1
   温度The mixture was slowly warmed at room temperature
2. 2
   その他The solvent was removed under reduced pressure
3. 3
   workup.DISSOLUTIONthe resulting white solid was dissolved in CHCl3
4. 4
   洗浄The organic phase was washed with water, brine
5. 5
   乾燥dried (MgSO4)
6. 6
   濃縮concentrated

実験手順

Cyclopropanesulfonyl chloride (5 g, 35 mmol, 1 eq) was dissolved in an excess BuOH (20 ml), the reaction mixture was cooled at −10° C. and pyridine (5.8 mL, 70 mmol, 2 eq) was slowly added dropwise. The mixture was slowly warmed at room temperature and stirred overnight. The solvent was removed under reduced pressure and the resulting white solid was dissolved in CHCl3. The organic phase was washed with water, brine and dried (MgSO4) and concentrated to give an oil (4.8 g, 24.9 mmol, 71%). 1H NMR (300 MHz, CDCl3): δ 4.25 (t, 2H), 2.46 (m, 1H), 1.74 (m, 2H), 1.45 (m, 2H), 1.25 (dd, 2H), 1.09 (dd, 2H), 0.93 (t, 3H).

出典