反応 #59517

反応方程式

3-(4-methoxyphenyl)-2-phenylacrylic acid

→

3-(4-methoxyphenyl)-2-phenylpropionic acid

溶媒

ethyl acetate

反応条件

後処理

1. 1
   workup.ADDITIONwas added under inert atmosphere
2. 2
   その他was hydrogenated at room temperature

実験手順

13 g of 3-(4-methoxyphenyl)-2-phenylacrylic acid was dissolved to 600 ml of ethyl acetate and 2.6 g of 10% palladium on charcoal was added under inert atmosphere. Starting material was hydrogenated at room temperature to give quantitative yield of 3-(4-methoxyphenyl)-2-phenylpropionic acid. 1H-NMR (400 MHz, d6-DMSO): 12.3 (bs, 1H), 7.32-7.20 (m, 5H), 7.1-7.0 (m, 2H), 6.8-6.7 (m, 2H), 3.79 (dd, 1H, J 6.9, 8.7 Hz), 3.70 (s, 3H), 3.22 (dd, 1H, J 8.7, 13.7 Hz), 2.87 (dd, 1H, J 6.9, 13.7 Hz).

出典