反応 #59443

反応方程式

piperidine

Malononitrile

2-fluorobenzaldehyde

→

title material

収率 28.3%

2-(2-Fluoro-benzylidene)-malononitrile

収率 28.3%

溶媒

iso-propyl acetate

反応条件

後処理

1. 1
   その他were placed in a vessel
2. 2
   その他which was irradiated in a 300 W single mode microwave for 15 seconds
3. 3
   ろ過filtered
4. 4
   その他evaporated
5. 5
   ろ過filtered through a pad of Magnasol
6. 6
   その他evaporated
7. 7
   その他recrystallized from ethanol

実験手順

Malononitrile (3.303 g, 50 mmol), 2-fluorobenzaldehyde (6.205 g, 50 mmol), 1 g of molecular sieves, and 500 mg of a resin bound piperidine (described in Tetrahedron Lett., 1999, 40, 7031-33) were placed in a vessel which was irradiated in a 300 W single mode microwave for 15 seconds. The reaction mixture was taken up in iso-propyl acetate, filtered, evaporated, taken up in dichloromethane, filtered through a pad of Magnasol, evaporated, and recrystallized from ethanol to yield 2.435 g of the title material as a crystalline solid,

出典