反応 #5944

反応方程式

thiophosgene

1,4-benzodioxan-6-amine

triethylamine

→

3,4-ethylenedioxyphenylisothiocyanate

収率 37.3%

溶媒

toluene

toluene

反応条件

後処理

1. 1
   温度cooled to room temperature
2. 2
   ろ過filtered
3. 3
   その他The filtrate was evaporated
4. 4
   workup.DISSOLUTIONThe product was redissolved in toluene
5. 5
   濃縮concentrated in vacuo
6. 6
   ろ過which was filtered
7. 7
   濃縮The filtrate was concentrated to a small volume, which

実験手順

To a mixture of 1,4-benzodioxan-6-amine (15.1 g; 100 mmol) and triethylamine (20.2 g, 200 ml) in toluene (350 ml) was added dropwise over 10 min. thiophosgene (11.5 g, 100 mmol) in toluene (50 ml). The mixture was stirred at 80° C. for 30 min., cooled to room temperature and filtered. The filtrate was evaporated. The product was redissolved in toluene and concentrated in vacuo. The resulting oil was taken up in warm petroleum ether, which was filtered. The filtrate was concentrated to a small volume, which afforded 7.2 g of 3,4-ethylenedioxyphenylisothiocyanate. 3,4-Ethylenedioxyphenylisothiocyanate (1.1 g; 5.7 mmol) in toluene (15 ml) was added to 3-[4-(2-chlorophenyl)piperazin -1-yl]propylamine (1.45 g, 5.7 mmol) in toluene (45 ml). The mixture was refluxed for 6 h, cooled to room temperature and purified by column chromatography on silica gel 60 eluting with toluene graduated to toluene/ethyl acetate (1:1). The product was triturated with petroleum ether and redissolved in ethanol. Addition of hydrogen chloride in ether precipitated the title compound, which was recrystallized from ethanol to give 180 mg. M.p. 210°-212° C. MS (70 eV): m/z 447 (M+, 1%), 445 (1), 295 (4), 193 (100), 166 (10), 151 (20).

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