反応 #59407

ord-43c4639d8ae24264a154cd6b8126972c

反応方程式

CN1C(=O)[C@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)Cc2ccccc21
(R)-3-(5-chloroindole-2-carbonylamino)-1-methyl-3,4-dihydrocarbostyril
CC(C)(C)OC(=O)N[C@@H]1Cc2ccccc2NC1=O
(R)-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril
O=C(N[C@@H]1Cc2ccccc2NC1=O)c1cc2cc(Cl)ccc2[nH]1
(S)-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril
O=C(N[C@@H]1Cc2ccccc2NC1=O)c1cc2cc(Cl)ccc2[nH]1
(R)-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril
→
CN1C(=O)[C@@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)Cc2ccccc21
title compound
CN1C(=O)[C@@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)Cc2ccccc21
(S)-3-(5-chloroindole-2-carbonylamino)-1-methyl-3,4-dihydrocarbostyril

反応物

CN1C(=O)[C@H](NC(=O)c2cc3cc(Cl)ccc3[nH]2)Cc2ccccc21
(R)-3-(5-chloroindole-2-carbonylamino)-1-methyl-3,4-dihydrocarbostyril
CC(C)(C)OC(=O)N[C@@H]1Cc2ccccc2NC1=O
(R)-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril
O=C(N[C@@H]1Cc2ccccc2NC1=O)c1cc2cc(Cl)ccc2[nH]1
(S)-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril
O=C(N[C@@H]1Cc2ccccc2NC1=O)c1cc2cc(Cl)ccc2[nH]1
(R)-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

The title compound was prepared from (S)-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril (prepared in Example 5) by the procedures described for the preparation of (R)-3-(5-chloroindole-2-carbonylamino)-1-methyl-3,4-dihydrocarbostyril (Example 14) from (R)-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril. HPLC/MS [M+H]+, 354.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07425550B2uspto-grants-2008_09