反応 #59391

反応方程式

water

compound

4-(3-cyclopentyloxy-4-difluoromethoxyphenyl)-4-cyanopiperidine Hydrochloride

potassium carbonate

ethyl bromoacetate

→

title compound

2-(4-(3-cyclopentyloxy-4-difluoromethoxyphenyl)-4-cyanopiperidin-1-yl)acetic Acid Ethyl Ester

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   抽出was extracted by tert-butyl methyl ether (160 ml)
2. 2
   洗浄The organic layer was washed by water (80 ml×2)
3. 3
   濃縮concentrated

実験手順

To a solution of the compound prepared in example 1 (19.8 g) in N,N-dimethylformamide (53 ml) were added potassium carbonate (18.4 g) and ethyl bromoacetate (5.89 ml) and the mixture was stirred for 1.5 hours at 50° C. To the reaction mixture was added water (160 ml) and it was extracted by tert-butyl methyl ether (160 ml). The organic layer was washed by water (80 ml×2) and concentrated to give the title compound (23.4 g) having the following physical data.

出典