反応 #59366

反応方程式

Water

lithium hydroxide monohydrate

biphenyl-3-yl acetic acid methyl ester

→

biphenyl-3-yl acetic acid

溶媒

methanol

反応条件

後処理

1. 1
   その他the organics were removed under reduced pressure
2. 2
   抽出extracted with chloroform (2×100 mL)
3. 3
   乾燥dried (MgSO4)
4. 4
   その他evaporated under reduced pressure

実験手順

Water (39 mL), followed by lithium hydroxide monohydrate (4.2 g, 101.5 mmol) were added to a solution of biphenyl-3-yl acetic acid methyl ester (11.43 g, 50.57 mmol) in methanol (265 mL). The mixture was stirred at ambient temperature for 2 h then the organics were removed under reduced pressure. The mixture was acidified with dilute hydrochloric acid (1M, 80 mL), extracted with chloroform (2×100 mL), dried (MgSO4) and evaporated under reduced pressure to afford biphenyl-3-yl acetic acid as a white solid, yield 10.6 g, (99%), analytical HPLC Rt=16.565 min, HPLC-MS (single main UV peak with Rt=7.91 min, 213.1 [M+H]+).

出典