反応 #59280

反応方程式

Carbonic acid (S)-1-[(S)-5-(2-benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-ylcarbamoyl]-ethyl ester 4-nitro-phenyl ester

2,2,3,3,3-penta-fluoropropylamine

→

title compound

(2,2,3,3,3-Pentafluoro-propyl)-carbamic acid (S)-1-[(S)-5-(2-benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-ylcarbamoyl]-ethyl ester

反応条件

後処理

1. 1
   その他After evaporation of all volatile components and chromatography on silica (gradient of heptane/ethyl acetate 0 to 80%)

実験手順

Carbonic acid (S)-1-[(S)-5-(2-benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-ylcarbamoyl]-ethyl ester 4-nitro-phenyl ester (65 mg, 0.11 mmol) and 2,2,3,3,3-penta-fluoropropylamine (663 mg, 4.3 mmol) were stirred for 24 h at ambient temperature. After evaporation of all volatile components and chromatography on silica (gradient of heptane/ethyl acetate 0 to 80%), the title compound was obtained as white solid (>98%). MS: m/e=606(M+H+).

出典