反応 #59244

反応方程式

compound

4-Chloro-7-(3,4-dihydroxy-5-hydroxymethyl-3-methyl-tetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde

tosylmethyl isocyanide

K2CO3

→

2-(4-Chloro-5-oxazol-5-yl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol

反応条件

後処理

1. 1
   温度the mixture is heated
2. 2
   温度to reflux
3. 3
   その他is consumed
4. 4
   その他The solvent is removed in vacuo
5. 5
   その他the crude mixture purified by RP HPLC on a Phenominex column (250×20 mm)
6. 6
   その他over 30 minutes

実験手順

To the compound from Step 1 is added tosylmethyl isocyanide (1 eq.) in MeoH containing K2CO3 (1 eq.) and the mixture is heated to reflux until starting material is consumed. The solvent is removed in vacuo and the crude mixture purified by RP HPLC on a Phenominex column (250×20 mm) using a gradient of acetonitrile in water from 0 to 30% over 30 minutes at 10 mL/minute.

出典