反応 #59240

ord-63a38c226fc942f48e15721c8dc0e18a

反応方程式

CON
methoxylamine
C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1ncc2c(NO)ncnc21
nucleoside
C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1ncc2c(NO)ncnc21
1-(2′-C-methyl-β-D-ribofuranosyl)-4-hydroxylamino-pyrazolo[3,4-d]pyrimidine
→
CONc1ncnc2c1cnn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@]1(C)O
Nucleoside
CONc1ncnc2c1cnn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@]1(C)O
1-(2′-C-methyl-β-D-ribofuranosyl)-4-methoxylamino-pyrazolo[3,4-d]pyrimidine

反応物

CON
methoxylamine
C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1ncc2c(NO)ncnc21
nucleoside
C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1n1ncc2c(NO)ncnc21
1-(2′-C-methyl-β-D-ribofuranosyl)-4-hydroxylamino-pyrazolo[3,4-d]pyrimidine

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Nucleoside 119 was prepared from the nucleoside 143 (Example 6, step 3) substituting hydroxylamine for methoxylamine.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07425547B2uspto-grants-2008_09