反応 #59173

反応方程式

1,2-diamino-4,5-difluorobenzene

cyanogen bromide

sodium bicarbonate

→

5,6-difluoro-1H-benzimidazol-2-amine

収率 98.8%

溶媒

water

反応条件

後処理

1. 1
   濃縮was then concentrated in vacuo
2. 2
   温度heated
3. 3
   温度at reflux for 15 minutes
4. 4
   ろ過The hot suspension was filtered
5. 5
   洗浄rinsing with hot ethanol
6. 6
   濃縮the filtrate was concentrated in vacuo

実験手順

Step 1 The procedure used was similar to that reported in J. Med. Chem. 40:811-818, 1997. A solution of 1,2-diamino-4,5-difluorobenzene (500 mg, 3.47 mmol) in water (5 mL) was cooled to 0° C. and then treated with a solution of cyanogen bromide (0.83 mL, 4.16 mmol, 5 M in acetonitrile) and solid sodium bicarbonate (583 mg, 6.94 mmol). The solution was stirred at rt overnight and was then concentrated in vacuo. The dark residue was suspended in ethanol and heated at reflux for 15 minutes. The hot suspension was filtered, rinsing with hot ethanol, and the filtrate was concentrated in vacuo to afford 5,6-difluoro-1H-benzimidazol-2-amine (580 mg, 59%), which was used in the next step without further purification. LC-MS m/z 170.2 (MH+), ret. time 0.85 min; 1H NMR (300 MHz, DMSO-d6) δ 6.30 (br s, 2H), 7.06 (dd, 2H), 10.79 (br s, 1H).

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