反応 #59127

反応方程式

[4-(methoxycarbonyl)tetrahydro-2H-pyran-4-yl]acetic acid

Thionyl chloride

→

methyl 4-(2-chloro-2-oxoethyl)tetrahydro-2H-pyran-4-carboxylate

収率 99.0%

反応条件

後処理

1. 1
   その他The solvent was then removed
2. 2
   その他mixture was azeotroped with dichloroethane three times

実験手順

Thionyl chloride (20 mL) was added to [4-(methoxycarbonyl)tetrahydro-2H-pyran-4-yl]acetic acid (970 mg, 4.80 mmol) and the solution was stirred at rt for 3 h. The solvent was then removed and mixture was azeotroped with dichloroethane three times to afford methyl 4-(2-chloro-2-oxoethyl)tetrahydro-2H-pyran-4-carboxylate (1.05 g, 99%), which was used without purification in the next step.

出典