反応 #59102

反応方程式

2-(2-fluoro-5-nitrophenyl)-2-methyloxirane

BF3

→

2-(2-fluoro-5-nitrophenyl) propanal

溶媒

ethyl ether

反応条件

後処理

1. 1
   その他Solution was then quenched with water
2. 2
   抽出extracted with ethyl ether
3. 3
   洗浄Organics washed with brine
4. 4
   乾燥dried with sodium sulfate
5. 5
   濃縮concentrated
6. 6
   その他Crude product was purified

実験手順

2-(2-fluoro-5-nitrophenyl)-2-methyloxirane (1 eq) was dissolved in ethyl ether (1 mL) under nitrogen. BF3-etherate (0.87 eq) was added dropwise at room temperature and after complete addition solution was allowed to stir for 1 h. Solution was then quenched with water, extracted with ethyl ether. Organics washed with brine, dried with sodium sulfate and concentrated. Crude product was purified using flash chromatography (85% Hex: 15% EtOAc) on silica to afford 2-(2-fluoro-5-nitrophenyl) propanal.

出典