反応 #59072

反応方程式

3-(tert-butyl)phenylamine

sodium bicarbonate

thiophosgene

→

3-(tert-butyl)benzenisothiocyanate

溶媒

acetone

反応条件

後処理

1. 1
   その他was brought to ambient temperature
2. 2
   濃縮concentrated
3. 3
   その他partitioned between ethyl acetate and water
4. 4
   乾燥The organic layer was dried with sodium bicarbonate and sodium sulfate
5. 5
   濃縮concentrated

実験手順

To 3-(tert-butyl)phenylamine in acetone at 0° C. was added sodium bicarbonate (2 eq) and thiophosgene (2 eq). The mixture was brought to ambient temperature and concentrated and partitioned between ethyl acetate and water. The organic layer was dried with sodium bicarbonate and sodium sulfate and concentrated to yield 3-(tert-butyl)benzenisothiocyanate. MS: MH+=192.

出典