反応 #59063

反応方程式

sodium hydroxide

ethylpiperidine-4-carboxylate

2-bromo-1-methoxyethane

potassium carbonate

→

1-(2-methoxyethyl)piperidine-4-carboxylic acid

溶媒

ethanol

water

ethanol

反応条件

後処理

1. 1
   温度was refluxed for 16 h
2. 2
   ろ過The mixture was then filtered
3. 3
   濃縮concentrated
4. 4
   その他The resulting 1-(2-methoxyethyl)piperidine-4-carboxylic acid was then azeotroped with toluene

実験手順

To ethylpiperidine-4-carboxylate (1 eq) in ethanol was added 2-bromo-1-methoxyethane (1 eq) and potassium carbonate 2 eq) and the resulting mixture was refluxed for 16 h. The mixture was then filtered and concentrated. To it was then added ethanol and water (3:1) and sodium hydroxide (1 eq) and it was refluxed for 16 h. The resulting 1-(2-methoxyethyl)piperidine-4-carboxylic acid was then azeotroped with toluene. MS: MH+=188.

出典