反応 #59009

反応方程式

water

Benzyl bromide

benzyl 4-benzoyloxy-2-hydoxybenzoate

cesium carbonate

→

benzyl 4-benzoyloxy-2-benzyloxybenzoate

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   抽出The resulting mixture was extracted with ethyl acetate
2. 2
   洗浄The organic layer was washed with water and brine
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   その他The solvent was evaporated under reduced pressure
5. 5
   その他the residue was purified by medium-pressure liquid silica gel column chromatography (eluent: n-hexane/ethyl acetate=6/1)

実験手順

Benzyl bromide (0.80 mL) was added to a mixture of benzyl 4-benzoyloxy-2-hydoxybenzoate (2.23 g) and cesium carbonate (2.29 g) in N,N-dimethylformamide (10 mL) at room temperature. The mixture was stirred at 50° C. for 3 hrs, and water was added. The resulting mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by medium-pressure liquid silica gel column chromatography (eluent: n-hexane/ethyl acetate=6/1) to afford benzyl 4-benzoyloxy-2-benzyloxybenzoate (2.87 g).

出典