反応 #58991

反応方程式

N-[4-(ethoxycarbonylmethyl)phenyl]-3-(1,5-diphenyl-1H-pyrazol-4-yl)propionamide

sodium hydroxide

hydrochloric acid

→

(4-{[3-(1,5-diphenyl-1H-pyrazol-4-yl)propanoyl]amino}phenyl)acetic acid

収率 94.0%

溶媒

ethanol

反応条件

後処理

1. 1
   ろ過the precipitated crystals were collected by filtration
2. 2
   洗浄washed with water
3. 3
   その他dried

実験手順

A mixture of N-[4-(ethoxycarbonylmethyl)phenyl]-3-(1,5-diphenyl-1H-pyrazol-4-yl)propionamide (0.76 g), a 1N aqueous sodium hydroxide solution (5 ml) and ethanol (5 ml) was stirred at 50° C. for 3 hrs. The reaction mixture was poured into a 1N aqueous hydrochloric acid solution and the precipitated crystals were collected by filtration, washed with water and dried to give (4-{[3-(1,5-diphenyl-1H-pyrazol-4-yl)propanoyl]amino}phenyl)acetic acid.

出典