反応 #5898

反応方程式

7-amino-[5H]indeno[1,2-c]pyridazin-3(2H)-one hydrochloride

4H-pyran-4-one

ammonia

→

title compound

7-(4-Oxo-1,4-dihydropyridin-1-yl)-[5H]indeno[1,2-c]pyridazin-3(2H)-one

溶媒

water

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度under reflux for 1 hour in a nitrogen atmosphere
3. 3
   その他to give a solid, 0.9 g, m.p. >300° C
4. 4
   その他This solid was triturated
5. 5
   温度with warm dilute hydrochloric acid
6. 6
   洗浄washed with water

実験手順

A stirred mixture of 7-amino-[5H]indeno[1,2-c]pyridazin-3(2H)-one hydrochloride (1.0 g) and 4H-pyran-4-one (0.48 g) in water (10 ml) was heated under reflux for 1 hour in a nitrogen atmosphere. The warm mixture was neutralised with aqueous ammonia to give a solid, 0.9 g, m.p. >300° C. This solid was triturated with warm dilute hydrochloric acid and washed with water to give the title compound, 0.42 g, m.p. >300° C.

出典