反応 #589017

反応方程式

2-(4-Acetylaminophenoxy)-propionic acid methyl ester

2-(4-Acetylamino-phenoxy)-propionic acid methyl ester

→

9

収率 98.1%

2-(4-Amino-phenoxy)-propionic acid

収率 98.1%

溶媒

HCl

反応条件

後処理

1. 1
   workup.DISTILLATIONExcess conc. HCl was distilled off in vacuum
2. 2
   ろ過filtered hot
3. 3
   ろ過filtered
4. 4
   その他dried

実験手順

2-(4-Acetylaminophenoxy)-propionic acid methyl ester 8 (320 g, 1.35 mol) in conc. HCl (8 L) was refluxed for 48 hours. Excess conc. HCl was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 9 (240 g, 81.7%) as a brown powder with an m.p between 175-180° C.

出典