反応 #5889

反応方程式

2-tert-butyl-6-isothiocyanato-5-(4-methylpiperidin-1-yl)benzothiazole

piperazine

→

2-tert-butyl-5-(4-methyl-piperidin-1-yl)-6-[(piperazin-1-yl)thiocarbonylamino]benzothiazole

収率 69.6%

溶媒

chloroform

反応条件

後処理

1. 1
   洗浄washed with water
2. 2
   乾燥dried over anhydrous sodium sulphate
3. 3
   その他evaporated
4. 4
   その他to get a sticky residue which
5. 5
   その他is triturated with isopropanol
6. 6
   ろ過filtered

実験手順

A solution of 3.45 g of 2-tert-butyl-6-isothiocyanato-5-(4-methylpiperidin-1-yl)benzothiazole, described in Example 1, and 8.6 g of anhydrous piperazine in 30 ml of chloroform is stirred for 3 hours, washed with water, dried over anhydrous sodium sulphate and evaporated to get a sticky residue which is triturated with isopropanol and filtered to obtain 3 g of 2-tert-butyl-5-(4-methyl-piperidin-1-yl)-6-[(piperazin-1-yl)thiocarbonylamino]benzothiazole, melting at 278°-281°.

出典