反応 #588526

反応方程式

4-Thieno[2,3-d]isoxazol-3-yl-piperazine-1-carboxylic acid tert-butyl ester

HCl

→

solids

収率 97.3%

3-piperazin-1-yl-thieno[2,3-d]isoxazole

収率 97.3%

反応条件

後処理

1. 1
   その他The volatiles were removed in vacuo
2. 2
   その他the residue was triturated with ether (twice)

実験手順

4-Thieno[2,3-d]isoxazol-3-yl-piperazine-1-carboxylic acid tert-butyl ester (5.0 g, 16.2 mmol) was stirred at room temperature in a solution of HCl (25 mL, 4N HCl in dioxane) for 4 hours. The volatiles were removed in vacuo and the residue was triturated with ether (twice) to yield off white solids 3.3 g (84%) as the desired hydrochloride salt.

出典