反応 #58790

反応方程式

gabapentin hydrochloride

Thionyl chloride

gabapentin hydrochloride

thionyl chloride

gabapentin

benzyl alcohol

gabapentin hydrochloride

thionyl chloride

gabapentin hydrochloride

→

product ( 6 )

収率 91.0%

Benzyl 1-Aminomethyl-1-Cyclohexane Acetate Hydrochloride

収率 91.0%

溶媒

ethyl ether

反応条件

後処理

1. 1
   その他A dry 500 mL, three-necked, round-bottomed flask was fitted with a magnetic stirring bar and a 60 mL pressure-equalizing addition funnel
2. 2
   その他flushed with nitrogen gas
3. 3
   workup.STIRRINGto stir at room temperature for 4 h (LC/MS
4. 4
   温度cooled to 0° C.
5. 5
   workup.STIRRINGwhile stirring
6. 6
   その他White crystalline solid formed
7. 7
   ろ過which was collected by filtration
8. 8
   その他The crude compound was recrystallized from a mixture of ethanol and ethyl ether (50 mL: 150 mL.) Finally the white crystals
9. 9
   洗浄were washed with 250 mL of ethyl acetate

実験手順

A dry 500 mL, three-necked, round-bottomed flask was fitted with a magnetic stirring bar and a 60 mL pressure-equalizing addition funnel and flushed with nitrogen gas. The flask was charged with gabapentin (17.1 g, 0.1 mol) and benzyl alcohol (128 mL, 1.18 mol) and the mixture was cooled to 0° C. with an ice-water bath. Thionyl chloride (51.8 mL, 77.25 g, 0.65 mol) was added dropwise to the stirred solution over a period of 1 h. The reaction was monitored by LC/MS, with product and unreacted gabapentin hydrochloride being observed. After stirring at room temperature for 3.5 days the reaction mixture contained residual gabapentin hydrochloride (by LC/MS). Additional thionyl chloride (20 mL, 30 g, 0.25 mol) was added at 0° C., and the reaction mixture allowed to stir at room temperature for another 12 h (LC/MS shows traces of residual gabapentin hydrochloride). A final portion of thionyl chloride (10 mL, 15 g, 0.12 mol) was added at 0° C. and the reaction mixture allowed to stir at room temperature for 4 h (LC/MS showed no remaining gabapentin hydrochloride). The reaction mixture was then diluted with ethyl ether (200 mL) and cooled to 0° C. while stirring. White crystalline solid formed, which was collected by filtration. The crude compound was recrystallized from a mixture of ethanol and ethyl ether (50 mL: 150 mL.) Finally the white crystals were washed with 250 mL of ethyl acetate to give product (6) as a white solid (27 g, 91% yield). 1H NMR (CDCl3, 400 MHz.): δ 1.43-1.52 (m, 10H), 2.64 (s, 2H), 3.08 (d, 2H), 6.04 (br. s, 1H), 7.25-7.33 (m, 5H), 8.44 (br. s, 3H). MS (ESI) m/z 262.26 (M+H+).

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