反応 #587472

ord-938ff1a6ba1045d4870558362cce92be

反応方程式

CC(=O)O.Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12
bazedoxifene acetate
O=C1O[C@H]([C@@H](O)CO)C(O)=C1O
ascorbic acid
OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
lactose
CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
magnesium stearate
→
Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12
Bazedoxifene

反応物

CC(=O)O.Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12
bazedoxifene acetate
O=C1O[C@H]([C@@H](O)CO)C(O)=C1O
ascorbic acid
—
cellulose
OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
lactose
—
sodium starch glycolate
CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
magnesium stearate
—
AVICEL PH101

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

The procedure is similar to that of Example 1, except that the amounts of the components used are: bazedoxifene acetate (1,128 g), AVICEL PH101® (microcrystalline cellulose) (4,036 g), lactose NF (fast flow; 4,036 g), ascorbic acid (300 g), sodium starch glycolate (400 g) and magnesium stearate (100 g).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07771744B2uspto-grants-2010_08