反応 #58740

反応方程式

NaH

3-piperidin-1-yl-propan-1-ol

2-bromo-5-piperidin-1-ylmethyl-pyridine

→

title compound

5-Piperidin-1-ylmethyl-2-(3-piperidin-1-yl-propoxy)-pyridine

溶媒

DMF

反応条件

後処理

1. 1
   workup.WAITAfter 18 h
2. 2
   抽出the reaction is extracted with ethyl acetate (100 mL)
3. 3
   洗浄washed with 1 N NaHCO3 (50 mL) and H2O(3×50 mL)
4. 4
   その他The organic layer is dried
5. 5
   濃縮concentrated
6. 6
   その他chromatographed on SiO2

実験手順

To a suspension of NaH (1.5 mmol) in DMF is added 3-piperidin-1-yl-propan-1-ol (1.1 mmol). After 30 min, 2-bromo-5-piperidin-1-ylmethyl-pyridine (1 mmol) is added to the mixture. After 18 h, the reaction is extracted with ethyl acetate (100 mL) and washed with 1 N NaHCO3 (50 mL) and H2O(3×50 mL). The organic layer is dried, concentrated, and chromatographed on SiO2 to provide the title compound.

出典