反応 #58623

反応方程式

methyl 2-({[(trichloroacetyl)amino]carbonyl}amino)thiophene-3-carboxylate

bromine

→

title compound

Methyl 5-bromo-2-({[(trichloroacetyl)amino]carbonyl}amino)thiophene-3-carboxylate

溶媒

acetic acid

acetic acid

反応条件

後処理

1. 1
   workup.ADDITIONAfter the addition
2. 2
   その他The solvent was evaporated under vaccum
3. 3
   その他the residue was triturated with H2O

実験手順

To a stirred solution of methyl 2-({[(trichloroacetyl)amino]carbonyl}amino)thiophene-3-carboxylate (1 eq) in glacial acetic acid (20 mL) was added a solution of bromine (1.3 eq) in glacial acetic acid (5 mL) slowly over a period of 5 min. After the addition was complete, the resulting dark solution was stirred for 30 mins at RT. The solvent was evaporated under vaccum and the residue was triturated with H2O. The title compound was obtained by filtration (99%) as an off-white solid. The product was used in the next step without any further purification after drying for 2 days under P2O5. LC/MS (ES, M+H=425).

出典