反応 #586133

反応方程式

4-(5-chlorothiophen-2-yl)-2-fluorobenzonitrile

S-cyclopropylmethylisothiourea hydrobromide

→

4-(5-chlorothiophen-2-yl)-2-cyclopropylmethylthiobenzonitrile

収率 91.0%

反応条件

後処理

1. 1
   その他to react in the same manner

実験手順

0.9 g (4.0 mmol) of 4-(5-chlorothiophen-2-yl)-2-fluorobenzonitrile and 0.9 g (4.3 mmol) of S-cyclopropylmethylisothiourea hydrobromide were allowed to react in the same manner as described above in Example 8 (4), and purification of the crude product by silica gel column chromatography afforded 1.1 g of 4-(5-chlorothiophen-2-yl)-2-cyclopropylmethylthiobenzonitrile (yield 91%) as yellow feathery crystals (m.p. 123-124° C.).

出典