反応 #586121

反応方程式

1-[5,5,8,8-tetramethyl-4-(2-ethoxyethoxy)-5,6,7,8-tetrahydronaphth-2-yl]prop-2-yn-1-ol

hydrochloric acid

→

(R)-1-[5,5,8,8-Tetramethyl-4-(2-ethoxyethoxy)-5,6,7,8-tetrahydronaphth-2-yl]prop-2-yn-1-ol

収率 41.0%

溶媒

—

solution

K2CO3

methanol

heptane

vinyl acetate

反応条件

後処理

1. 1
   workup.ADDITION7.26 g of enzyme PS30 are added
2. 2
   ろ過the reaction medium is filtered
3. 3
   濃縮concentrated under reduced pressure
4. 4
   その他Two products are separated out by chromatography
5. 5
   workup.STIRRINGthe medium is stirred for 3 hours
6. 6
   抽出extracted with ethyl acetate
7. 7
   その他The residue obtained
8. 8
   その他is purified by chromatography (eluent: 8/2 heptane/EtOAc)
9. 9
   その他A colorless oil is obtained (m=15 g, yield=41%)

実験手順

36 g (110 mmol) of 1-[5,5,8,8-tetramethyl-4-(2-ethoxyethoxy)-5,6,7,8-tetrahydronaphth-2-yl]prop-2-yn-1-ol (Example 2b) are dissolved in 75 mL of heptane and 10.2 ml of vinyl acetate. 7.26 g of enzyme PS30 are added, and the reaction medium is stirred and heated to 38° C. After 72 hours, the reaction medium is filtered and concentrated under reduced pressure. Two products are separated out by chromatography: 1-[5,5,8,8-tetramethyl-4-(2-ethoxyethoxy)-5,6,7,8-tetrahydronaphth-2-yl]prop-2-yn-1-ol (R)-acetate and (S)-1-[5,5,8,8-tetramethyl-4-(2-ethoxyethoxy)-5,6,7,8-tetrahydronaphth-2-yl]prop-2-yn-1-ol, which will be used for Example 5.18 g (48 mmol) of 1-[5,5,8,8-tetramethyl-4-(2-ethoxyethoxy)-5,6,7,8-tetrahydronaphth-2-yl]prop-2-yn-1-ol (R)-acetate are thus dissolved in 500 mL of a 2% solution of K2CO3 in methanol and the medium is stirred for 3 hours. The reaction medium is then treated with 0.01N hydrochloric acid solution and extracted with ethyl acetate. The residue obtained is purified by chromatography (eluent: 8/2 heptane/EtOAc). A colorless oil is obtained (m=15 g, yield=41%).

出典