反応 #586113

反応方程式

N-{(S)-1-hydroxy-3-phenyl-2-propyl}-5-benzyloxy-2-hydroxybenzamide

→

N-{(S)-1-hydroxy-3-phenyl-2-propyl }-2,5-dihydroxybenzamide

収率 85.0%

溶媒

methanol

反応条件

後処理

1. 1
   その他In a flask equipped with a magnetic stirring bar
2. 2
   その他Nitrogen is bubbled through the solution and 10% Pd on charcoal
3. 3
   workup.ADDITIONis added
4. 4
   その他After flushing with nitrogen
5. 5
   その他The suspension is flushed with nitrogen
6. 6
   ろ過filtered
7. 7
   洗浄rinsed over Celite
8. 8
   濃縮The filtrate is concentrated under vacuum

実験手順

In a flask equipped with a magnetic stirring bar and a rubber septum is dissolved the N-{(S)-1-hydroxy-3-phenyl-2-propyl}-5-benzyloxy-2-hydroxybenzamide in methanol. Nitrogen is bubbled through the solution and 10% Pd on charcoal is added. After flushing with nitrogen, the suspension is placed under hydrogen atmosphere and stirred for 2 hours. The suspension is flushed with nitrogen and filtered and rinsed over Celite. The filtrate is concentrated under vacuum. In this fashion is obtained N-{(S)-1-hydroxy-3-phenyl-2-propyl }-2,5-dihydroxybenzamide (85%).

出典