反応 #586102

反応方程式

N-(2-methyl-3-(1,1-dimethylpropyl)phenyl)form-amide

potassium hydroxide

methanol

→

3-(1,1-dimethypropyl)-2-methyl-phenylamine

溶媒

water

反応条件

後処理

1. 1
   温度at reflux temperature for 15 hours
2. 2
   workup.ADDITIONis added
3. 3
   抽出the reaction mixture is extracted with ethylacetate
4. 4
   乾燥After drying of the organic phase over sodium sulfate and evaporation of the solvent in a water jet vacuum
5. 5
   その他the product is purified by destillation (bp. ca. 70° C., 13,33 Pa)

実験手順

2,21 g (10.77 mmol) N-(2-methyl-3-(1,1-dimethylpropyl)phenyl)form-amide, 1,42 g (21.54 mmol) 85% potassium hydroxide and 9 ml methanol are heated under stirring at reflux temperature for 15 hours. After cooling 100 ml of water is added and the reaction mixture is extracted with ethylacetate. After drying of the organic phase over sodium sulfate and evaporation of the solvent in a water jet vacuum, the product is purified by destillation (bp. ca. 70° C., 13,33 Pa). This gives 1.7 g of 2-Methyl-3-(1,1-dimethylpropyl)phenylamine in the form of a colourless oil (89% of theory).

出典