反応 #586100

反応方程式

product

2-(2-Nitrophenyl)-3-(trimethylsilyl)-2-propene

hydrogen

→

2-(2-aminophenyl)-3-(trimethylsilyl)-propane

収率 88.0%

溶媒

tetrahydrofurane

反応条件

後処理

1. 1
   ろ過The catalyst was filtered off
2. 2
   その他after evaporation of the solvent
3. 3
   その他the product was chromatographed on silacagel (eluent: 10% ethylacetate in hexane)

実験手順

The reaction product of step A [7.2 g] was hydrogenated in tetrahydrofurane over palladium on charcoal at atmospheric pressure and room temperature until the uptake of hydrogen ceased. The catalyst was filtered off and, after evaporation of the solvent, the product was chromatographed on silacagel (eluent: 10% ethylacetate in hexane) to yield 2-(2-aminophenyl)-3-(trimethylsilyl)-propane [4.7 g; 88% purity according to NMR]. This product was used in the next step without further purification.

出典