反応 #586086

反応方程式

pyrrolidine

chloroacetyl chloride

→

N-(2-chloroacetyl)pyrrolidine

収率 85.4%

溶媒

dichloromethane

反応条件

後処理

1. 1
   洗浄The organic phase was washed with solutions of sodium hydrogen sulphate and sodium carbonate
2. 2
   その他dried
3. 3
   その他After evaporation of the solvent

実験手順

3.82 moles of pyrrolidine were added to a solution of 1.92 moles of chloroacetyl chloride in 600 ml of dichloromethane. The temperature was maintained at 0° C. The organic phase was washed with solutions of sodium hydrogen sulphate and sodium carbonate and dried. After evaporation of the solvent, 242 g of N-(2-chloroacetyl)pyrrolidine were obtained. 1.64 moles of this compound were dissolved in 500 ml of toluene and 231 ml of triethylamine were added. This was heated under reflux for 3 hrs and after cooling 311.5 g of product were isolated in the form of a precipitate. 119.07 g of the product obtained were dissolved in

出典