反応 #586079

反応方程式

tetradecyl 4-nitrobenzoate

ethyl acetate

→

tetradecyl 4-aminobenzoate

収率 65.2%

溶媒

Dichloromethane

反応条件

後処理

1. 1
   その他Under a nitrogen purge
2. 2
   その他for sixteen hours
3. 3
   ろ過the reaction mixture was filtered through a layer of CELITE
4. 4
   ろ過filter aid
5. 5
   濃縮The filtrate was concentrated under reduced pressure to a tan solid
6. 6
   その他The solid was recrystallized from ethanol

実験手順

Under a nitrogen purge, 10% platinum on carbon (2.5 grams) was added to a mixture of tetradecyl 4-nitrobenzoate (25 grams, 69 mmol) and ethyl acetate (250 milliliters) in a Parr vessel. The vessel was placed under hydrogen pressure (49 psi, 3.3×105 Pa) for sixteen hours. Dichloromethane was added and the reaction mixture was filtered through a layer of CELITE filter aid. The filtrate was concentrated under reduced pressure to a tan solid. The solid was recrystallized from ethanol to obtain 15 grams of tetradecyl 4-aminobenzoate as light tan needles.

出典