反応 #58601

反応方程式

triethylamine

dimethylsulphoxide

oxalyl chloride

76

(4-Benzyl-morpholin-2-yl)-cyclopropyl-methanol

→

Cyclopropyl[4-(phenylmethyl)morpholin-2-yl]methanone

溶媒

DCM

DCM

water

DCM

反応条件

後処理

1. 1
   workup.STIRRINGstirring
2. 2
   workup.WAITcontinues for 15 minutes
3. 3
   その他the layers are separated

実験手順

A solution of dimethylsulphoxide (0.69 mL, 9.7 mmol, 2.2 eq) in DCM (4.5 mL) is slowly added to a solution of oxalyl chloride (2.43 mL, 4.85 mmol, 1.1 eq) in DCM (2.5 mL) followed by a solution of 76 (1.09 g, 4.41 mmol) in DCM (0.7 mL) under nitrogen at −60° C. After stirring for 15 minutes, triethylamine (3.14 mL, 22.1 mmol, 5 eq) is added and stirring continues for 15 minutes. After addition of water, the layers are separated.

出典