反応 #58536

反応方程式

product

1-Benzyl-4-(4-bromo-thiophen-2-yl)-pyrrolidine-3-carboxylic acid

oxalyl chloride

→

subtitle compound

収率 100.0%

1-Benzyl-4-(4-bromo-thiophen-2-yl)-pyrrolidine-3-carbonyl chloride

収率 100.0%

溶媒

CH2Cl2

反応条件

後処理

1. 1
   その他Next, the solvent was evaporated in vacuo

実験手順

A solution of the product from step c) (4.6 g, 12.6 mmol) in CH2Cl2 (63 ml) was treated with DMF (3-5 drops) and oxalyl chloride (2.4 g, 18.9 mmol) for 2 hours. Next, the solvent was evaporated in vacuo to give 4.04 g (100%) of the subtitle compound that was used without further purification.

出典