反応 #58524

反応方程式

product

1-Benzyl-4-(4,5-dibromo-thiophen-2-yl)-pyrrolidine-3-carboxylic acid tert-butyl ester

trifluoroacetic acid

→

1-Benzyl-4-(4,5-dibromo-thiophen-2-yl)-pyrrolidine-3-carboxylic acid trifluoroacetate

溶媒

CH2Cl2

反応条件

後処理

1. 1
   その他Next, the solvent was evaporated
2. 2
   workup.ADDITIONtoluene (50 ml) was added
3. 3
   その他subsequently evaporated in vacuo at 40° C.
4. 4
   その他to remove residual TFA
5. 5
   その他The crude subtitle product was used without further purification

実験手順

The product of step b) (2.6 g, 5.2 mmol) in CH2Cl2 (25 ml) and trifluoroacetic acid (TFA) (75 ml) was stirred at 220C for 16 hours. Next, the solvent was evaporated and toluene (50 ml) was added and subsequently evaporated in vacuo at 40° C. to remove residual TFA. The crude subtitle product was used without further purification.

出典