反応 #58479

反応方程式

4-Cyano-tetrahydro furane 3-carboxylic acid methyl ester

SOCl2

water

→

4-cyano-2,5-dihydro furane 3-carboxylic acid methyl ester

収率 90.0%

溶媒

pyridine

反応条件

後処理

1. 1
   抽出extracted with benzene
2. 2
   その他Combined extracts were dried
3. 3
   濃縮concentrated in vacuo

実験手順

4-Cyano-tetrahydro furane 3-carboxylic acid methyl ester was dissolved in 4.9 ml of pyridine and treated with 4.4 ml (60 mmol) of SOCl2 during 90 min under nitrogen at 4° C. The resulting solution was warmed to room temperature, stirred for 6 hours and poured into 40 ml water at 4° C. and extracted with benzene. Combined extracts were dried and concentrated in vacuo to give 90% yield of 4-cyano-2,5-dihydro furane 3-carboxylic acid methyl ester.

出典