反応 #58478

反応方程式

KCN

4-oxo-tetrahydro furane 3-carboxylic acid methyl ester

H2SO4

→

4-cyano-tetrahydro furane 3-carboxylic acid methyl ester

溶媒

water

ether

反応条件

後処理

1. 1
   その他Then the organic solution was separated
2. 2
   洗浄the salts were washed twice with benzene
3. 3
   乾燥dried over sodium sulfate
4. 4
   濃縮concentrated in vacuo

実験手順

To a stirred solution of 3.9 g (60 mmol) KCN in 5.5 ml of water at 4° C., a solution of 2.9 g (20 mmol) of 4-oxo-tetrahydro furane 3-carboxylic acid methyl ester in ether (26 ml) was added. To the precipitate of salts, 3.5 ml H2SO4 (18 N) was added and stirred for 16 hours. Then the organic solution was separated, the salts were washed twice with benzene, dried over sodium sulfate and concentrated in vacuo to give 4-cyano-tetrahydro furane 3-carboxylic acid methyl ester.

出典