反応 #58439

反応方程式

4-methanesulfonylphenylamine

thiophosgene

→

1-isothiocyanato4-methanesulfonylbenzene

収率 85.2%

溶媒

water

hydrochloric acid

反応条件

後処理

1. 1
   ろ過the suspension was filtered
2. 2
   洗浄washed with water
3. 3
   乾燥dried over P2O5

実験手順

A solution of 4-methanesulfonylphenylamine (2.4 g, 14 mmol) was dissolved in a mixture of water (30 mL) and hydrochloric acid (9 mL, 37%). This was treated drop wise at room temperature with thiophosgene (1.5 g, 13.2 mmol) with good stirring. After 1 h, the suspension was filtered, washed with water and dried over P2O5 to give 2.4 g (85% yield) of 1-isothiocyanato4-methanesulfonylbenzene. 1H NMR (CDCl3), 300 MHz δ3.09 (s, 3H, CH3), 7.41(d, 2H, Aromatic), 7.98 (d, 2H, Aromatic).

出典